Cardioprotective role of Justicia traquebareinsis Linn. Local consumers of the leaves are mostly . Data were analyzed using one-way analysis of variance (ANOVA) using Statistical Product and Service Solutions (SPSS) version 17.0 and results were expressed as meanSEM. In-vivo studies have revealed that radicals produced from these dietary antioxidants are constantly regenerated back to their active form by GSH in the ascorbate glutathione cycle. Ashwagandha tea: 10 benefits, side effects and recipes, 7 interesting health facts about Black sapote fruits. It is also composed of vitamins and minerals good for heart health. Eyong EU, Umoh IB, Ebong PE, Eteng MU, Antai AB, Akpa AO. They can easily tolerate acidic to slightly alkaline sandy, loamy, and clay soils. A multidisciplinary overview of intoxicating snuff rituals in the western hemisphere. Whether added to garden beds or pots, the justicia (plant) adds a colorful tropical touch and are easy to grow. 200, 500 and 1000 mg/kg bw of Justicia carnea showed a significant (p<0.05) decrease in the activities of ALT, AST and ALP, and bilirubin level while total protein and albumin levels increased significantly (p<0.05) when compared with the rats treated with CCl alone. It is an awesome plant and worth your time and attention. Mean lethal dose of the extract was found to be above 5000mg/kg body weight (bw). Chidubem Olovo is a biochemist and a researcher whose interest is centered on the chemistry of natural products, their pharmacological properties and how using the plant sources can improve human healthy living. Further study assessing the kidney indices (urea, creatinine and electrolytes) is however encouraged to ascertain the safety of the plant extract on renal function. Ewe eje or ewe ajeri is prepared differently by different folks. How to make Ewe eje Extracthow to prepare justicia carnea. However, further research needs to done to determine the mode of action of the plant, and it's effects on humans. J Ethnopharmacol 2000;70(2):151-159. 1. Despite the avalanche use of medicinal plant, preliminary toxicity studies remain essential tools to ensure safe consumption and prevent unexpected toxicity that could arise from long term exposure. The appropriate dose of Justicia pectoralis depends on several factors such as the user's age, health, and several other conditions. As declared by all authors, no competing interests exist. Kone WM, Koffi AG, Bomisso EL, Tra Bi FH. Buege JA, Aust SD. International Journal of Biochemistry Research & Review. This study investigated the in-vitro antioxidant activity of ethanol leaf extract of Justicia carnea and its effect on antioxidant status of alloxan-induced diabetic albino rats. Hence, Justicia carnea can be used to strengthen the immune system. Keep in mind that natural products are not always necessarily safe and dosages can be important. In the study conducted by Onyeabor and his colleagues, it was shown that the leaf extract not only reverses anemic condition, but also lowered the lipid profile of the experimental rats. This claim by traditional healers with regard to the efficacy of justicia carnea in the treatment diabetes have been researched on and it was found to be true. Superoxide dismutase was carried out using the method of Sun and Zigma [18]. Rich, well-drained soil retaining ample moisture is the perfect home for Brazilian plume flowers. The hematopoietic systems represent a sensitive target of toxic compounds and an essential index of physiological and pathological status in experimental animals [24]. The animals were allowed free access to rat chow and water ad libitum. Previously, J. carnea leaf has been reported to contain high quantity of phytochemical constituents (such as saponins, alkaloids and terpenoids), vitamins (A, C and E) and minerals [9, 10]. View abstract. It also grows in some Caribbean islands, including Trinidad and Tobago. While not necessary, prune the justicia (plant) freely to maintain the desired shape and size. These tropical plants are not very fussy about soil. 2010;4(8):6804 https://doi.org/10.5897/JMPR09.487. The mixture was incubated at 28C for 30min and the absorbance read at 550nm against the reagent blank. (2017). 217-230. Duan WL, Liang XM. Growing up, we were told many biblical stories, Negro pepper (Xylopia aethiopica) is a spice plant that possess several health benefits, which make it an indispensable, Eating for its sour taste when fairly ripen and sweet taste when well ripen, star apple finds favor, Fertility tree (Newbouldia laevis), also known as boundary tree, Ogirisi in Igbo, Adikuru in Hausa and Ewe akoko, Guava (Psidium guajava) is a well known tropical tree which is widely grown for its fruits. Tissues were stained with haematoxylin and eosin, mounted on glass slides and examined under a standard light microscope. Ewe eje or Ewe ajeri is known by the Igbo tribe as Ogwu obara. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. The perennial plant puts on a never-ending show of radiant flowers from early spring to fall. Another health benefit of ewe eje leaves is in cardiac protection and hypolipidemic effect. Phytother Res 2011;25(3):444-450. The aim of this study is to evaluate the effects of J. carnea leaf extract on hematology indices and organ antioxidant system in healthy wistar rats. Ani, Onuabuchi & Udedi, Stanley & Asogwa, Kingsley & Enemali, Michael & Onwelumadu, Chigozie & Ikedife, Kenneth. Blooming from early summer to fall, the flowers are attractive to hummingbirds and butterflies. Diallo A, Gbeassor M, Vovor A, Eklu-Gadegbeku K, Aklikokou K, Agbonon A. Further, 0.5ml of supernatant was treated with 0.5ml of Ellmans reagent (containing 19.8mg of 5,5 dithiobis - (2-nitrobenzoic acid) (DTNB) in 100ml of 0.1% sodium nitrate) and 3.0ml of phosphate buffer (0.2M, pH8.0). Catalase activity (U/ml) was measured following the method of Sinha [17]. Proximate analysis of the aqueous extract of J. carnea leaves showed that it contains appreciable amounts of 53.07 0.07% carbohydrate, 9.26 0.02% ash, and 26.71 0.02% . So lets go through this together. Ethanol extract of J. carnea leaf elevated red blood cell, hemoglobin, packed cell volume and platelet count with significant increase at higher doses of extracts compared to the control. Filed in Biochemistry Project Topics, Current Projects by TMLT Editorials on September 22, 2020. In Nigeria, the leaf of Justicia carnea is usually prepared with edible vegetables to make soup, boiled separately in water to make tea or prepared by cooking with other medicinal plants for therapeutic purposes. The animals were randomly distributed into cages and allowed to acclimatize for 2 weeks in a well ventilated room under natural lighting condition. The protein content may help in cellular functions and are building blocks for structural and functional biomolecules. Justicia carnea is a medicinal plant that is used conventionally as blood tonic from time immemorial in Nigeria. A total number of forty two (42) male albino rats weighing between 120 and 170g were used in this study. Based on estimation by World Health Organization (WHO), larger percentage (between 80 and 90%) of the worlds population especially in developing countries depends on traditional system of medicine [1, 2]. Only plants will be removed from the collection. Ethanol extracts of J. carnea leaf increased RBC, hemoglobin and platelet with significant increase (p<0.05) in groups that received higher dose (>500mg/kg b.w) of extract compared to the control. Mr. T.S. Each rat was dissected and blood samples were collected by cardiac puncture using 5mL into tubes containing ethylenediaminetetraacetic acid (EDTA) for hematological analysis. But like in the case of depression and hepatitis, other species of justicia have been studied and proven to be antiepileptic. 2011;5(9):48992 https://academicjournals.org/journal/AJPS/article-full-text-pdf/6AA410310867. It has been reported previously that under certain conditions, dietary antioxidants such as ascorbic acid, tocopherol and carotenoids could act, occasionally, as pro-oxidants to initiate slight degree of oxidative stress microenvironment. 2005 - 2023 WebMD LLC, an Internet Brands company. Onoagbe IO, Attah V, Luther MM, Esekheigbe A. Hypoglycemic and anti-diabetic effects of Morinda lucida and Tetracera alnifora in normal and streptozotocin-induced diabetic rats. However, serious caution of the dose should be taken into consideration when extrapolating this result for human consumption. The description of these plants has been written based on numerous outside resources. Anthonia OC, Ikechukwu UR, Uzoma NO, Sunday ELU. It is cultivated and sold as a decorative potted plant and is planted in landscaping as a feature plant in warm . It helps in replenishing blood lost during period. 2015;15:236. https://doi.org/10.1186/s12906-015-0760-y. It may be, judging from the antidepressant activity of other plant of justicia species whose activity have been studied, proper to state that justicia carnea may possess antidepressant properties. Niger J Physiol Sci. African J Plant Sci. Arch Toxicol. You can add the leaves and water altogether in a pot and allow to boil till the water turns red. PubMed MacRae, W. D. and Towers, G. H. Justicia pectoralis: a study of the basis for its use as a hallucinogenic snuff ingredient. However, there have not been scientific backing on this claim, yet, from the antiviral properties of other species of justicia, it could be that this plant possess antiviral properties which is utilized in the treatment of hepatitis infection. 2005;102(2):197201. The higher LD50 (>5000mg/kg body weight) of J. carnea leaf ethanol extract suggested that the ethanol extract is experimentally safe and not toxic. We'll respect your privacy and unsubscribe at any time. WBC reduced in rats treated with doses of J. carnea with significant decrease (p<0.05) in rats that received 50, 100 and 1200mg/kg body weight. In a pot, pour in a cup of water and bring to a boil. Relative to the control, liver of rats treated with doses of J. carnea ethanol extract showed varied degree of hepatic injury in a dose dependent manner. Justicia carnea [jus-TEE-see-ah, KAR-nee-uh] is popularly known as the Brazilian Plume Flower. Related: The Persian Shield plant is also in the Acanthaceae family. This information may not fit your specific health circumstances. After 72h of soaking, the wine (dark purplish red) colored filtrate was filtered using a double cheese cloth, concentrated under reduced pressure using rotary evaporator and subsequently water bath at 40C to obtain a slurry (dark purple) extract termed Justicia carnea ethanol extract (JCEE). Acute and chronic toxicity of the aqueous extract of Artemisia afra in rodents. CAS Results obtained from the acute oral toxicity study revealed tolerance of experimental rat to acute administration of J. carnea ethanol extracts since no mortality and signs of toxicity were observed after 24h (Table1). It is very rich in iron, a major component is RBC hemoglobin. Ewe eje isnt capable of causing any side or negative effects if consumed moderately. Chariandy, C. M., Seaforth, C. E., Phelps, R. H., Pollard, G. V., and Khambay, B. P. Screening of medicinal plants from Trinidad and Tobago for antimicrobial and insecticidal properties. Rather it can assist with improveing liver function such as detoxification. Ewe eje is mainly given to persons who want a blood boost such as pregnant women, persons suffering from anemia and other convalescents. Relative to control, lymphocyte and granulocyte exhibited no significant difference in all doses while MID was elevated in treated groups with significant increase in rats administered with 500 and 800mg/kg body weight. 1.3.1 Aetiologyof Anaemia Anaemia may be due to a single factor such as a nutritional deficiency or multifactorial (McEvoy, 2013). In the winter, temperatures between 60 64 degrees Fahrenheit (15 18 C) are ideal. At this time there is not enough scientific information to determine an appropriate range of doses for Justicia pectoralis. It also grows in some Caribbean islands, including Trinidad and Tobago . The leaves are rich in carbohydrates and proteins, which are for energy production and maintenance of cellular activities. Total reaction mixture of 3ml contained 2.95ml of 0.05M sodium carbonate buffer (pH10.2), 0.02ml tissue sample and 0.03ml of epinephrine (2mM) in 0.005N HCl was used to initiate the reaction. Treatments of all experimental animals were performed following Principle of Laboratory Animal Care manual guidebook of National Institute of Health as approved by the Research Ethics Committee of Olusegun Agagu University of Science and Technology, Okitipupa, Ondo State. In traditional medicine, justicia carnea is used in treating hepatitis. Influence of ethanolic extracts of dried fruit of Xylopia aethiopica (Dunal) A. Vitamin B aids in the formation of red blood cells and helps to build tissues. The cuttings should be placed in individuals pots and put under glass or shaded location, away from direct sunlight. 400). The possible anti-anaemic property of the leaf could be linked to the improved hemoglobin, PCV and RBC observed in this study. (2020). 1999;9:18. Justicia pectoralis is a flowering herb that grows in tropical areas of the Americas, including South and Central America. What this means is that aside fighting anemia, justicia carnea leaves also improves your cardiovascular health by suppressing the tendency for dyslipidemia. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. Cite this article. Research reports it isnt capable of causing kidney and liver damage either but dont eat it raw. If you provide us with your name, email address and the payment of a modest $25 annual membership fee, you will become a full member, enabling you to design and save up to 25 of your garden design ideas. https://doi.org/10.1016/j.jep.2007.02.011. Omogunwa is a graduate of Biochemistry from the Department of Chemical Sciences, Olusegun Agagu University of Science and Technology, Okitipupa, Ondo State, Nigeria. Yes my readers. what are the pros and cons of testosterone replacement therapy? The liver and kidney of rats administered with 500mg/kg JCEE and above demonstrated slight increase in MDA level with significant (P<0.05) increase only observed in the liver of rats that received 1200mg/kg of extract. Powdered sample was extracted using absolute ethanol and concentrated to obtain a slurry paste of J. carnea ethanol extracts. Ewe eje can also be used to manage abnormalities associated with anaemia and for the treatment and management of diabetics. The absorbance was taken at interval of 1min for 3min at 480nm. The unique and beautiful tubular flowers of Justicia carnea highlight the plant. This requires more attention to properly document the various health benefits of justicia carnea. This special leaf can be found around us- in our neighborhood. Philadelphia: WB. 2002;82:197205. Cassani, J., Dorantes-Barrn, A. M., Novales, L. M., Real, G. A., & Estrada-Reyes, R. (2014). The Health benefit of Ewe eje (Justicia carnea leaf) are highlighted in this article. Compared to the control, total protein in liver and kidney were statistically not altered except rats that were administered with 1200mg/kg JCEE that showed significant (p<0.05) decrease in the liver. J Ethnopharmacol. The present study investigated the antioxidant and in vitro antidiabetic capacities of Justicia carnea aqueous leaf extract (JCAE) using -amylase inhibition model. The haematological indices of the blood samples were determined using an automated URIT 2900 Plus 3 Differential Haematological Analyzer. Manage cookies/Do not sell my data we use in the preference centre. The Brazilian Plume is native to mainly tropical areas in South America, meaning it thrives in warm and slightly humid climates. Contamination of medicinal plant could be as a result of contaminants (such as heavy metals, aflatoxin and pathogenic microbes) from soil and manner of herbal preparations [4]. Aim. 2003;84:99104. CAS International Journal of Phytomedicine and Phytotherapy, Clinical Phytoscience The kidney of rats treated with doses of J. carnea ethanol extract revealed dose dependent degree of renal injury (Fig. It is also known as Jacobinia carnea, and is a part of the Acanthaceae family along with the Aphelandra squarrosa (Zebra plant) and Crossandra. J Ethnopharmacol 1999;64(3):265-270. In a reaction mixture containing 0.01M phosphate buffer (pH7.0), 0.5ml of 0.2M H2O2 and 0.4ml distilled water, 0.5ml of sample was added. Nutritive properties of aqueous extract Justicia carnea leaves and its effects on haematological and some biochemical indices of anaemia induced male wistar albino rats. Justicia carnea belongs to the family- Acanthaceae. You can add milk or honey for taste before drinking. I also conduct research on molecular basis of human diseases, linking the pharmacological properties of certain natural products and their mechanisms of actions to the treatment of such diseases. Clinical Guide to Laboratory tests. B-vitamins are good sources of energy. While histology of organs showed no adverse pathological lesions in the internal organs of rats, higher dose (1200mg/kg) over a period of time could cause noticeable liver and kidney injury. Justicia carnea (belonging to Acanthaceae family) is a flowering plant consisting ~600 species that are widely distributed in the tropics and subtropics [7]. At the end of 14th day of administration, rats were allowed to fast overnight, sacrificed to collect samples for biochemical analysis and histopathological examination. One of the side-effects of some orthodox drugs used in the past had been excessive inhibition of the carbohydrate-hydrolyzing enzymes, which in turn leads to abdominal discomfort and. Ewe eje as it is fondly called by the Westerners in Nigeria is a plant known for its blood boosting abilities. This plant is somewhat drought-tolerant once established but looks best with regular watering during periods of extended dry weather. Hepatic and renal damage has been recently linked with the use of medicinal plants in the treatment of various diseases [5, 6]. Join now and start creating your dream garden! Meth Enzymol. Mukinda JT, Syce JA. aqueous extract J. carnea leaves and its effects on haematological and some biochemical indices of anaemia induced male Wistar albino rats. Ogwu obara can act as a blood tonic for women during menstruation. In phase two, three rats were separated into 3 groups of one rat per group. Aim. Not sure which Justicia to pick?Compare All Justicia. One of the numerous nutritional benefits of justicia carnea leaves is in the possession of various forms of the B vitamins such as Vitamin B1, B2, B6, B9, and B12. He earned B.Sc. The renal cortex showed normal glomeruli with mesangial cells and capsular spaces appeared normal (white arrow), the renal tubules appear normal (blue arrow) and interstitial spaces also observed normal (black arrow). Kidney weight of rats treated with JCEE showed no significant difference with exception in 800mg/kg JCEE that demonstrated significant reduction. View abstract. Sample (or standard solution) (0.01ml) was mixed with diluted (1:4v/v distilled water) biuret reagent (100mM sodium hydroxide, 16mM sodium-potassium tartrate, 15mM potassium iodide and 6mM copper sulphate). Despite the use of Justicia carnea and other reported scientific studies, there are no reports on its effects on the major organs of the body. California Privacy Statement, Terms and Conditions, The significant decrease in kidney GSH at 1200mg/kg could be due to ample dietary bioactive constituents in the extract that requires frequent conjugation of GSH in the cell or oxidation to oxidized glutathione (GSSG). The plants cannot be propagated with seeds. Side effects of Ewe eje (Justicia carnea leaf Side Effects). Grows up to 4-6 ft. tall (120-180 cm) and 2-3 ft. wide (60-90 cm). Onyeabo C, Achi NK, Ekeleme-Egedigwe CA, Ebere CU, Okoro CK. According to acute toxicity grading standards, LD50 of substances greater than 5000mg/kg is practically considered non-toxic [22, 23]. 2018;2018:5762368. Springer Nature. Anaemia is a common blood disorder that affects people of all ages, though people at greater risk are the elderly, young women and infants. Too much fertilizer is damaging for your plant. Cookies, This site is protected by reCAPTCHA and the Google, Justicia scheidweileri (Purple Shrimp Plant), Justicia americana (American Water-Willow), Want Garden Inspiration? It is believed by local consumers in Ghana to possess anti-anaemic effects that boost blood levels in pregnant women, anaemic patients and also . Be careful about the moisture in the soil, avoiding letting it dry completely. J. Appl. 3rd ed. It results from one or more of the following events: loss of red blood cells (RBCs), reduction in the production of RBCs, increased destruction of RBCs, and shorter life span of RBCs (McEvoy, 2013). Author ESA managed the literature searches and wrote the first draft of the manuscript with the assistant of FOA. https://doi.org/10.35841/biomedicalresearch.30-18-666. The spread is equally glorious and can take up 12 15 inches of space. View abstract. Radhika J, Sathya S, Jothi G, Japasheba JL. Venancio, E. T., Rocha, N. F., Rios, E. R., Feitosa, M. L., Linhares, M. I., Melo, F. H., Matias, M. S., Fonseca, F. N., Sousa, F. C., Leal, L. K., and Fonteles, M. M. Anxiolytic-like effects of standardized extract of Justicia pectoralis (SEJP) in mice: Involvement of GABA/benzodiazepine in receptor. Article The aim of this study is to evaluate the safety of ethanol extract of J. carnea leaf assessing the hematology indices, organ antioxidant system and histology in healthy male wistar rats. The botanical name- Justicia carnea was coined after a scotish- James Justice, who happens to have found the plant first. The ameliorative effect of Justicia carnea on blood glucose level and lipid profile in alloxan-induced diabetic albino rats was evaluated in a study titled, "Effects of methanol leaves extract . and M.Sc. One of the oldest known plant is the fig tree. View abstract. Mapanga RF, Musabayane CT. This copyrighted material is provided by Natural Medicines Comprehensive Database Consumer Version. Photomicrograph of a liver sections stained with Haematoxylin and Eosin (Mag. The catalase activity was calculated using the expression: Note: A=change in absorbance, TV=total volume, TP=total protein, SV=sample volume, =molar extinction=40M1 cm1. Safety assessment of Uvaria chamae root extract: acute and subchronic toxicity studies. statement and Why urban citizens in developing countries use traditional medicines: the case of suriname. Superoxide dismutase (SOD) activities were elevated across all doses in the liver with significant (p<0.05) difference only observed in the highest dose (1200mg/kg) while kidney showed no significant difference compared to the control. 3 . Cut from the stem, some fresh or dried Justicia carnea leaves. The unique flower clusters and bright coloring has made it a popular choice among landscape artists and amateur gardeners as well. For a few weeks, the cutting should be watered every day to promote root development. The result of hematology indices is presented in Table3. However, caution should be taken as higher dose at 1200mg/kg could cause noticeable tissue injury. One of the health benefits of justicia carnea is in boosting immune system. It is nicknamed the Blood leaf, Blood of Jesus, and Jehovah Witness leaf in Nigeria, and is a widely used leaf across states in Nigeria. Fitoterapia. How Justicia Betonica is effective for various diseases is listed in repertory format. Justicia carnea is commonly cultivated and grown as an ornamental potted plant. Make sure to follow the package instructions carefully. Google Scholar. Haematoxic effects following ingestion of Nigerian crude oil and crude oil polluted shellfish by rats. The species Justicia secunda Vahl belongs to the family - Acanthaceae - together with up to 600 other shrubs and herbs species. Sedlak J, Lindsay RH. long (25 cm), and showy flower plumes, 8 in. de Smet, P. A. Article -Amylase binding-interaction with JCAE was also investigated using fluorescence spectroscopy and molecular docking. Ren Fail. Microsomal lipid peroxidation. Except the group that received 1200mg/kg JCEE which showed significant (p<0.05) elevation of SOD and MDA in the liver, other doses (<1200mg/kg) demonstrated no significant difference compared to the control. View abstract. Prof. F.O. PubMed This study has confirmed the safety of ethanol extract of J. carnea leaf and validates its conventional use as blood booster. Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. In a study conducted by Onyeabor and colleagues, the leaf extract of jusiticia carnea reverses the anemic effect of phenylhydrazine on the pack cell volume, red blood cell, and hemoglobin concentrations. The leaves of Justicia carnea contains powerful antioxidant activities and phytochemical components that help reduce oxidative stress, and reduce the risk of development of cancer.
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